Michael Gale, Jr., PhD, is a Professor in the Department of Immunology at The University of Washington, School of Medicine. CiteScore: 5.2 ℹ CiteScore: 2019: 5.2 CiteScore measures the average citations received per peer-reviewed document published in this title. Title. Modern Virology Assays for Antiviral Drug Discovery, Vaccine Development and Pathogenesis Investigation. RIG-I is expressed at a low level in most cells of the body and its abundance increases in response to IFN. Congratulations Dr. Gale! RIG-I signaling is propagated through its signaling adaptor protein MAVS to drive activation of innate immunity. 7737-7747. Verified email at uw.edu - Homepage. He is the Director of the UW Center for Innate Immunity and Immune Disease (CIIID), Associate Director of the Center for Emerging and Re-emerging Infectious Diseases (CERID), is an Adjunct Professor in the Departments of Microbiology and Global Health, and is an Affiliate Member of Vaccine and Infectious Disease Division of the Fred Hutchinson Center Research Center. . A major is to define therapeutic targets to enhance innate immunity for the control of virus infection, enhancing vaccine efficacy, and as anti-cancer immuno-therapeutics. Gale, M & Horvath, CM 2015, ' Editorial overview: Antiviral strategies ', Current Opinion in Virology, vol. During infection, IL-1β production occurs in parallel with the onset of innate antimicrobial defenses, but the contribution of IL-1β signaling to cell-intrinsic immunity is no … Gender Diversity distribution of the Editors, Benchmark Gender Diversity distribution across Virology & Vaccinology portfolio Editors, University of Washington Department of Immunology, Seattle, Washington, United States of America, Download the ‘Understanding the Publishing Process’ PDF, Check the status of your submitted manuscript in the. He is also a Core Staff Scientist of the Washington Regional Primate Research Center. Michael Gale, Eileen M. Foy. Virology Papers Virology, Nebraska Center for 11-8-2019 Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control ... Cristian Apetrei, Ivona Pandrea, and Michael Gale Jr. var addthis_product = 'wpp-262'; Articles Cited by. Esther Francisco, Mehul S. Suthar, Michael Gale, Amy B. Rosenfeld, Vincent R. Racaniello> ;Virology. Fredericksen, BL, Smith, M, Katze, MG, Shi, PY & Gale, M 2004, ' The host response to West Nile Virus infection limits viral spread through the activation of the interferon regulatory factor 3 pathway ', Journal of virology, vol. Gale is an expert in innate immunity, virology, immunology, cytokine biology, virus/host interactions, and immune signaling. Careers - Terms and Conditions - Privacy Policy. Sort. His research focuses on understanding the molecular processes of innate immunity and inflammation, including the role of each in immune recognition, control of virus infection, and immune programming. Cookies are used by this site. CiteScore values are based on citation counts in a range of four years (e.g. He was an international leader in the application of genome sequencing, animal models, and systems biology approaches to virology and immunology.Katze was formerly Professor of Microbiology at the … 12, pp. Hosts: Vincent Racaniello and Michael Gale. Together, these 10 publications were cited an average of 254 times per year, and have been cited over 2,228 times in manuscripts written by other researchers in the field. The research in these papers covers a broad range of topics, including Immunology, Microbiology, Parasitology, Virology, Cell Biology Biochemistry, Experimental Medicine and Multidisciplinary sciences. This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $75-$500 off a Drobo. HCV associates with host apolipoproteins and enters hepatocytes through complex processes involving some combination of CD81, claudin-1, occludin, and scavenger receptor BI. Michael Gale (Jr.), University of Washington Department of Immunology, Seattle, Washington, United States of America RNA viruses, innate immunity, interferon, cytokine, pathogenesis, , Thomas Gallagher, Loyola University Chicago Microbiology and Immunology Department, Maywood, … Editor's Personal Website, Copyright © 2021 Elsevier B.V. The lab leverages their research findings toward developing innate immune therapeutics for application in antiviral treatment and vaccine enhancement to combat emerging viruses. Dr. Gale is a Professor with the University of Washington Department of Immunology, as well as the Director of the Center for Innate Immunity and Immune Disease (CIIID).. Antiviral strategies, edited by Michael Gale and Curt M Horvath Virus structure and expression, edited by Yizhi Tao and Eric Jan Receive an update when the latest issues in this journal are published Read more about the methodology here. innate immunity virology infectious disease immunology systems biology. Immunologist and virologist, Dr. Gale conducts cutting-edge singlet oxygen research. Search Virology. Biology, Virology; View Abstract Article Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus. Science. Page 5 of 53. Here … Source Normalized Impact per Paper (SNIP). Hepatitis D virus (HDV), the only known deltavirus until 2018, has been found only in humans, and its coinfection with hepatitis B virus (HBV) is linked with fulminant hepatitis. This highly anticipated annual list identifies scientists and social scientists who produced multiple papers ranking in the top 1% by citations for their field and year of publication, demonstrating significant research influence among their peers. This is a collaborative lecture series between the Virology and Gene Therapy (VGT) Track of the Mayo Graduate School and the Institute for Molecular Virology. ABSTRACT Hepatitis C virus (HCV) infection is sensed in the host cell by the cytosolic pathogen recognition receptor RIG-I. In non-infected cells RIG-I is found in a resting state with the RD covering the RNA-binding and helicase domains (Saito et al., 2007).CARDs of ‘resting’ RIG-I are also folded over one another with these interactions governing the signaling activity of RIG-I (Fig. However, HCV blocks RIG-I signaling through viral NS3/4A protease cleavage of MAVS on the mitochondrion-associated endoplasmic reticulum (ER) membrane (MAM). Rights and Permissions. This form is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. 78, no. 14, pp. https://doi.org/10.1016/j.coviro.2015.05.001 Additionally, The Gale laboratory has active research programs focused on understanding immune control of infection by Studies with mice lacking the common plasma membrane receptor for type I interferon (IFN-αβR -/-) have revealed that IFN signaling restricts tropism, dissemination, and lethality after infection with West Nile virus (WNV) or several other pathogenic viruses.However, the specific functions of individual IFN subtypes remain uncertain. Rights and Permissions. To decline or learn more, visit our Cookies page. Sanna M. Mäkelä, Pamela Österlund, Veera Westenius, Sinikka Latvala, Michael S. Diamond, Michael Gale, Ilkka Julkunen Infectious Diseases Division of Biology and Biomedical Sciences 2019 Feb 1 3 citations IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection. View in: Publisher Site Mentions: Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. Research in the Gale laboratory focuses on understanding the virus-host interactions that control innate immunity and viral disease, and on defining the molecular processes by which innate immunity controls the outcome of infection and immunity in response to emerging viral pathogens of … Help expand a public dataset of research that support the SDGs. In the past few years, Nexcelom Bioscience has worked with leading labs in the field of virology from government agencies, academic labs, and pharmaceutical companies such as the Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), and National Institute … Once production of your article has started, you can track the status of your article via Track Your Accepted Article. His laboratory works to define how virus/host interactions trigger and control innate immunity to direct the outcome of infection and the immune response. The fields are defined by sets of journals and exceptionally, in the case of multidisciplinary journals such as Nature and Science, by a paper-by-paper assignment to a field based on an analysis of the cited references in the papers. 1076: 2008: Overall, the United States is home to the highest number of Highly Cited Researchers, with 2,737 authors, representing 44% of the researchers on the list. For over 35 years, he has researched host-virus interactions, incorporating systems biology approaches into infectious disease research. The Journal of Virology. This episode is sponsored by Data Robotics Inc. Michael Gale Jr. will never forget the sound his ‘68 Mustang made when its engine roared back to life in 1993. The data are taken from 21 broad research fields within Essential Science Indicators, a component of InCites. ... Journal of virology 82 (1), 335-345, 2008. The University of Washington is home to 46 highly cited researchers for 2019. Deltaviruses need a coinfecting enveloped virus to produce infectious particles necessary for transmission to a new host. Sort by citations Sort by year Sort by title. Resources for Postdoctoral Fellows at the UW, JEM Career Launchpad Features Immunology Assistant Professor Elia Tait Wojno. TWiV 85: Hepatitis C virus with Professor Michael Gale. The car was given to him in 1977 by his father. Michael Gale (Jr.), PhD Editorial board, Virology University of Washington Department of Immunology, Seattle, Washington, United States of America Michael Gale, Jr., PhD, is a Professor in the Department of Immunology at The University of Washington, School of Medicine. MAVS Is Essential for Primary CD4+ T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection Huanle Luo, Evandro Winkelmann, Guorui Xie, Rong Fang, Bi-Hung Peng, Li Li, Helen M. Lazear, Slobodan Paessler, Michael S. Diamond, Michael Gale Jr., Alan D. Barrett, and Tian Wang J. Virol. Hosts: Vincent Racaniello and Michael Gale. 1999; 73 (8):6235–6244. His laboratory aims to define the processes of innate immunity that direct a successful immune response for the control of disease, and to understand the processes of virus-induced immune pathology. Michael Katze is an American microbiologist. Immunologist and virologist, Dr. Gale conducts cutting-edge singlet oxygen research. Michael Gale, Jr. University of Washinton. 1,464 Full-Text Articles 4,234 Authors 191,323 Downloads 95 Institutions All Articles in Virology Follow Faceted Search 1,464 full-text articles. This percentile-based selection method removes the citation advantage of older papers relative to recently published ones, since papers are weighed against others in the same annual cohort. For the third year in a row, Dr. Michael Gale Jr. remains one of the most highly cited researchers in the world. On episode 85 of the podcast This Week in Virology, Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses. Interleukin-1 beta (IL-1β) is a pleiotropic mediator of inflammation and is produced in response to a wide range of stimuli. Tagged as: antiviral, hcv, hepatitis, hepatitis C virus, hepatocellular carcinoma, liver cancer, michael gale, viral, virology, virus Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses. The full 2019 Highly Cited Researchers list and executive summary can be found here. var addthis_config = {"data_track_clickback":true,"data_track_addressbar":false};if (typeof(addthis_share) == "undefined"){ addthis_share = [];}. v-vii. Hosts: Vincent Racaniello and Michael Gale. Additionally, The Gale laboratory has active research programs focused on understanding immune control of infection by hepatitis C virus, hepatitis B viruses, HIV, SIV, flaviviruses including Zika virus and West Nile virus, Hanta virus, SARS-CoV-2 and contemporary coronaviruses, and influenza viruses. © 2021 University of Washington | Seattle, WA. When it was finally ready for the road, he had it painted its original Highland Green color, channeling Steve McQueen in Bullitt. Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses. 2003; 300:1145–1148. [PMC free article] Foy E, Li K, Wang C, Sumpter R, Ikeda M, Lemon SM, Gale M., Jr Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Immunology Professor Dr. Michael Gale Jr. Named one of the Most Highly Cited Researchers of 2019. RIG-I Signaling Is Essential For Influenza B Virus-Induced Rapid Interferon Gene Expression Sanna M. Mäkelä, Pamela Österlund, Veera Westenius, Sinikka Latvala, Michael S. Diamond, Michael Gale Jr., and Ilkka Julkunen J. Virol. Hepatitis C virus (HCV) infection is a major cause of liver disease. 6 June 2010 by Vincent Racaniello. Since 2011, Dr. Gale has published 10 manuscripts that the Web of Science has since classified as highly cited papers. | Seattle, WA ) infection is a major cause of liver disease public dataset of research that the. Hepatitis C virus ( HCV ) infection is sensed in the Department Immunology. Sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $ 75- $ off! 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